The HEATmarker® VVM2 is a label containing a heat-sensitive material which is placed on a vaccine vial to register cumulative heat exposure over time. The combined effects of time and temperature cause the inner square of the VVM2 to darken gradually and irreversibly.
The inner square of the VVM2 is made of heat-sensitive material that is initially light in color and becomes darker when exposed to heat (Fig. 1). The color change is faster at higher temperatures and slower at lower temperatures. At the discard point or end point, the inner square is the same color as or darker than the outer circle.
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